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Type II Collagen manufacturer

We are no strangers to collagen, and we will see it at any time in our daily lives. So what is type II collagen? What is its effect? The following is an explanation of type II protein.

Collagen type II is a kind of high molecular protein. The filamentous collagen fibers are interwoven with elastin and polysaccharide protein to form a network structure, which produces a certain mechanical strength. Collagen is the extracellular matrix. The earliest concern was the impact of cells on life activities. Through research, it was found that the extracellular matrix is ​​also very important for life.

In the past ten years, the extracellular matrix has been discovered, especially collagen and protein. Polysaccharides play a key role in human health and the occurrence of certain diseases. In the medical and health care market, more and more products related to collagen are being developed.

Specifications of Type II Collagen

Product NameType II CollagenProduct GradeGrade A
Raw MaterialChicken Sternum CartilageShelf time2 Years
AppearanceWhite or Light yellowQ/HSMN0008S-2016
OdorCharacteristic OdorQ/HSMN0008S-2016
Collagen Type II (dry basis)≥50%GB 5009.5
Chondroitin Sulfate≥20%GB/T20365
Hyaluronic Acid≥10%Internal
Moisture<10%GB 5009.3
Ash≤8%GB 5009.4
Total Aerobic Count≤1000 CFU/gGB 4789.2
ColiformsNegativeGB 4789.3
Molds/Yeast≤50 CFU/gGB 4789.15
As≤3 mg/kgGB 5009.11
Pb≤0.5 mg/kgGB 5009.12
Hg≤0.1 mg/kgGB 5009.17
Ca≤1 mg/kgGB 5009.92

The importance of supplementing collagen

No matter standing, sitting, walking or running, it will produce several times the pressure. If the body lacks enough collagen, it will easily affect our daily life; on the contrary, if the body’s collagen requirement can be met, it can help us maintain Flexible mobility, no matter whether it’s going out shopping, sports or traveling! Only by maintaining healthy activity ability can we enjoy the old life of playing around.

Recommended nutrient combination for type II collagen

Nutritionists suggest that you can take in nutrients such as glucosamine and chondroitin at the same time, as well as supplement vitamin C that promotes the formation of collagen, and vitamin D that promotes calcium absorption, double maintenance, and help the body quickly replenish nutrients and maintain health.


Glucosamine can be ingested from foods such as shrimp, shellfish, crabs, cartilage, yam, and kelp. If you are allergic to crustaceans, you should pay attention to the source of intake.


Chondroitin can be ingested from foods such as animal cartilage, chicken feet, and tendons, but because these foods contain more calories and fats, excessive supplementation must be avoided.

3、Vitamin C

Vitamin C is an important raw material for the synthesis of collagen and can promote the formation of collagen. Ingest foods rich in vitamin C such as guava, kiwi fruit, green vegetables, etc., together with the intake of various nutrients, can provide more comprehensive nourishment and health care, and strengthen the body’s flexibility.

4、Vitamin D

Vitamin D can help the growth and development of bones and teeth, help maintain the normal physiology of nerves and muscles, and strengthen mobility. Supplement vitamin D through foods such as dried shiitake mushrooms, salmon, milk or eggs, or get in the sun for about 10-15 minutes every day to help the body’s synthesis.


Omega-3 can be taken from salmon, mackerel, and sardines. Omega-3 supplementation can regulate physiological functions and enhance physical strength.
Supplementing nutrients is the key to maintaining good health. In addition, moderate exercise can also enhance physical flexibility, such as lying on your back on the bed or on the ground, slowly lifting your legs, 3 times a day, 1 time for about 15 seconds , Straight leg raise exercise strengthens quadriceps, maintain correct standing and sitting posture, avoid squatting, sitting cross-legged, kneeling sitting, and lifting the legs, try not to lift heavy objects or pay attention to the average weight of left and right hands, and squat when taking low objects Instead of bending down, you can reduce the pressure on your body parts; as long as you pay attention to these small details in daily life, you can develop health and flexibility!

The production process of non-denatured type II collagen

Collagen is a large family, it only exists in animals, and there is no collagen in plants. This is an important principle. In animals, collagen is distributed in bones, cartilage, skin, fascia, etc. Collagen is different from the double helix structure of other proteins, but a triple helix structure, which is composed of three long chains of amino acids rotating. Because of the different amino acid sequences of the long amino acid chain, different types of collagen are formed through different combinations, such as type I, II, III, IV, and V, which are distributed in different tissues. And type II collagen is mostly distributed in cartilage, so we should choose animal hyaline cartilage as the best material for extracting type II collagen.

1. Obtain cartilage materials that meet your needs.

The raw material is animal cartilage, such as pig joint cartilage, chicken joint cartilage, and chicken breast cartilage. After the raw materials are obtained, the raw materials cannot usually be used directly. There are often residual meat, perichondrial membranes, calcified lumps and other impurities on the top, which is time-consuming and labor-intensive to manually remove and increase the cost. In the present invention, the ratio of ProteaseN:pepsin=1:16 (w/w), respectively, under the environment of PH6.5 and PH2.5, stirred and hydrolyzed at 26°C~28°C for 24 hours, the result is that the impurities are basically removed , The cartilage material is complete in shape and meets the extraction requirements.

2. Crush the cartilage material into fine powder.

The cartilage material is put into a cryogenic grinder, and it can be crushed into fine powder at one time, and its fineness can reach 150~200 mesh. Because cartilage material extracts non-denatured type II collagen, the current commercially available equipment has the problem of grinding and heating, and the denaturation temperature of the extraction target is 39°C~41°C, so ordinary equipment cannot solve this problem.

3. Extract collagen.

Put the cartilage powder in the reaction tank, add 0.5mol/L acetic acid at 16°C~18°C, add (W/W) concentration of pepsin, stir for 24 hours, 10,000 revolutions/separate heart , Get the supernatant; take the supernatant, gradually add 9mol/L NaOH solution dropwise, adjust the pH to 6. 5~7.2; salting out, add NaCl to 4. Omo 1/L, stir to dissolve, use 12000 revolutions/separation of the heart, precipitation, the obtained precipitate is a crude product of non-denatured type II collagen.

4. Purify the obtained collagen.

Take advantage of the water-insoluble nature of collagen, wash the collagen with deionized water, stir it evenly, centrifuge at 12,000 rpm, repeat washing, stirring and centrifugation twice, the resulting precipitate is non-denatured type II with a purity of more than 95% Collagen.

Why is collagen lost?

Ageing will reduce the rate of collagen synthesis. Excessive activity and improper diet will also accelerate the consumption of collagen, making our body’s collagen unable to supply the body’s needs. Especially a large number of exercisers, elderly people with limited mobility, and workers who carry heavy objects are prone to loss of collagen due to sports injuries, poor posture, long-term weight bearing, and frequent standing for a long time. The intake of collagen must be strengthened to maintain the balance of collagen in the body.

What kinds of collagen are there?

Collagen accounts for 20% of the body’s total protein mass and has a strong ability to stretch. Common types of collagen in the body include Type I Collagen, Type II Collagen, Type III Collagen, Type IV Collagen, Type V Collagen and Type X Collagen, of which the first, third and fourth types of collagen exist on the surface, and the second type of collagen is related to flexibility Correlation is one of the important nutrients for athletes and silver-haired people to maintain their bodies. The following will introduce you two types of type 2 collagen, “denatured type 2 collagen” and “non-denatured type 2 collagen”

Denatured VS. Non-denatured Type II Collagen Effect

Denatured Type II Collagen

Denatured type 2 collagen is extracted with a “hydrolyzed” technology. After acidification or alkalization processing, it will give priority to retain complete activity, small molecules, and easier to be absorbed by the body. Take the recommended daily dose to help flexibility and increase daily activity . Therefore, when choosing denatured type 2 collagen products, it is recommended to evaluate the extraction technology first. The preferred choice is to not only retain more complete activity, but also hydrolyzed type 2 collagen with smaller molecules, which is easier to be absorbed by the body. Take the recommended daily dose , To help flexibility and increase daily activities, improve the quality of life.

Non-denatured type II collagen

The non-denatured type 2 collagen is mainly derived from low-temperature chicken breast cartilage extraction, which retains the complete three-strand spiral three-dimensional structure, but due to the large molecular weight, the active ingredients will not be decomposed by the digestive tract. It is recommended to choose products supported by experimental data, so that the authenticity can be more proved and convincing. Continuous daily supplementation can regulate physiological functions and help maintain health.

Which foods contain Type II Collagen?

Common type 2 collagen foods are: chicken cartilage, chicken feet, pig ears, and pig feet. However, the content of food is not high. If you eat more for the sake of ingestion, you may eat too much oil. Therefore, it is recommended to use health food to supplement enough type 2 collagen more conveniently and quickly!

Need to supplement Type II Collagen

No matter standing, sitting, walking or running, it will produce several times the pressure. If the body lacks enough collagen, it will easily affect our daily life; on the contrary, if the body’s collagen requirement can be met, it can help us maintain Flexible mobility, no matter whether it’s going out shopping, sports or traveling! Only by maintaining healthy activity ability can we enjoy the old life of playing around. Therefore, the following groups need to supplement type 2 collagen:
1. Mature elders
2. Housewives who often do housework
3. Heavy sports groups who love sports
4. Office groups who work long hours
5. Mountaineers who have been hiking and walking for a long time

When to eat Type II Collagen?

It is recommended to eat it “on an empty stomach” or “between meals”, such as the mid-range between the main meal and the main meal every day, or 2 hours after breakfast. Supplementing type II collagen will reduce the amount of gastric acid on an empty stomach, which can reduce the damage to the structure of type II collagen.

Contraindications for Type II Collagen

Those who are allergic to collagen should not use type II collagen.
Side effects of Type II Collagen
There are few studies on the side effects related to type 2 collagen, and it is safe to supplement it at the recommended dose. However, if the daily dose is as high as 40 mg for up to 24 weeks, stomach upset, headache, insomnia, dizziness and liver problems may occur.

Summary of type II collagen

Because type II collagen is the main component of human skin, and the most abundant human body is protein, it is mainly distributed in various organs of the human body. After the skin loses moisture, the weight of collagen accounts for 7%, which is responsible for providing elasticity and skin. The degree of firmness, and it is an important tissue that provides moisture to the skin, so the human body will experience dehydration and aging after the loss of collagen. This shows that it is necessary to supplement type II collagen.

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