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customization-capsule
home > Gelatin capsule sizes

Gelation capsule sizes

As a manufacturer of hard empty gelatin capsules and animal gelatin, the production and quality control for custom gelatin capsules are more guaranteed.Gelatin capsules with different raw materials, different sizes, different colors are available for customization. We have started to export hard gelatin capsule from 16 years ago. 

We know how to keep quality of capsule with well package and cool conditioner during transportation and storage. We also have enough experience to assist buyers to do custom clearance with correct documents and certificates. We Support the customization of packaging, private label and LOGO. Printing text in gelatin capsule are available too. Serving buyers from the bio-medicine, cosmetics, medical, nutrition and pharmaceutical industries.

Manufacture of Hard Gelatin Capsules

S1. Set the preheating temperature of the reaction tank to 60℃. After the temperature is reached, mix the dissolved gelatin and collagen at 8:2, and press Calculate the mass percentage by adding plasticizers and surfactants at the same time, so that various materials are fully mixed;

S2. Place the mixed glue obtained in the above steps in a water bath at a constant temperature of 40~70℃ and stir until a uniform flow is formed.Dripping wall material solution;

S3. Degas the above wall material solution ultrasonically, and then place it under vacuum pressure until the solution becomes clear and transparent.Form a uniform shell material;

S4. Transfer the degassed shell material into a preheated holding tank, set the temperature to 60°C for 4 hours, and prepare it for subsequent packaging bag;

S5. Dipping glue and cooling and solidifying operation through the capsule mold rod;

S6. Transfer the coagulated capsules to a constant temperature dryer, and set the drying temperature to 40-60°C and the drying time 45min;

S7. Pull out the blastocyst after it has regained moisture, cut it according to the required scale, and combine the cut capsule body and capsule Cap to obtain the finished capsule shell;

S8. Use ozone sterilization to sterilize the hollow capsules prepared in the above steps, set the ozone pressure to 0.2MPa, and when sterilizing The interval is 1~10min.

Hard Gelatin capsules could be made from animal gelatin capsule and Vegetarian gelatin capsule

Animal gelatin includes cow hide gelatin, custom bovine bone gelatin, custom pig skin gelatin, and custom fish gelatin. Some manufacturers will choose a combination of pig and cow. For example, bovine bone gelatin contributes to the firmness of the capsule. On the other hand, the selection of pigs has characteristics of plasticity and clarity.

Vegetarian gelatin capsule means that the film-forming material for hollow capsule production is non-animal origin and does not contain any animal-derived substances. For example, hypromellose hollow capsules, pullulan hollow capsules, hydroxypropyl starch hollow capsules, etc., 

Some products - gelatin capsules

Different sizes of Hard Gelatin capsules could be provided

There are standard size capsules that are named by numerical values. They are numbered: 000, 00, 0, 1, 2, 3, 4 and 5. These sizes are the same for all types of Gelatin, HPMC and Pullulan. The majority of capsule filling machinery are manufactured to be compatible with these standard sizes. Capsule size 00 is the largest capsule used for human oral preparations and size 5 is the smallest.

Opening the capsule, you can clearly see that the two parts of the capsule are of different sizes. The cap of the capsule is slightly larger than the capsule. Ordinary capsules are of two-stage type, and the larger diameter capsule cap covers the smaller capsule body to form a sealed state. Imagine that if two parts have the same color, it is difficult to distinguish between the lid and the container based on the similar size and diameter. Therefore, in order to ensure that production is not prone to errors, manufacturers use different colors to distinguish two parts of different calibers to avoid errors in mass production. One side of the capsule adopts a transparent shell, allowing users to see at a glance whether the inside of the capsule is granular or powder, which is convenient to use.

“000” holds about 1000 mg., “00” holds about 735 mg., “0” size holds
about 500 mg., #1 holds about 400 mg., #3 about 200 mg.
One teaspoon will fill about 7 “0” capsules and about 5 “00” capsules.

The weight depends on the density of the powder you are using. Some powders are much denser than others. It also depends on the fineness of the powder. The only way to be sure is to check the weight of each individual material. On a scale accurate to within one-tenth of a gram or even to one-tenth of an ounce or even to a gram, you can weigh 24 empty capsules and then compare with the weight when full. If you only want a small amount of active ingredient, then you can mix with a material such as milk powder or rice powder as a filler. That way you can use “0” or “00” size capsules with various weights of active ingredients.

capusle-size

“000” holds about 1000 mg., “00” holds about 735 mg., “0” size holds
about 500 mg., #1 holds about 400 mg., #3 about 200 mg.
One teaspoon will fill about 7 “0” capsules and about 5 “00” capsules.

The weight depends on the density of the powder you are using. Some powders are much denser than others. It also depends on the fineness of the powder. The only way to be sure is to check the weight of each individual material. On a scale accurate to within one-tenth of a gram or even to one-tenth of an ounce or even to a gram, you can weigh 24 empty capsules and then compare with the weight when full. If you only want a small amount of active ingredient, then you can mix with a material such as milk powder or rice powder as a filler. That way you can use “0” or “00” size capsules with various weights of active ingredients.

Hard Gelatin capsules with different colors could be chosen

We offer a variety of colors for empty gelatin capsules such as transparency,red,yellow, green,black,white and so on. Different colors make it easier for patients to distinguish drugs. Buyers can choose from our wide range of unique colors. Even if you produce multiple drugs, you can choose a different color for each drug. This will ensure that there is no dangerous confusion about the health of patients who already need treatment for specific diseases.

The transparent side is convenient for users to observe and reduce risks. Another reason is to cover up its unsightly appearance and make it easier for people to accept it from the senses. Especially for children, colored capsules make them less scared. Of course, the capsule does not have to be made in two colors. It can also be made into single color or transparent color.

What are the hard gelatin capsules we provide?

The hard gelatin capsules we provide consist of two cylindrical shells-each shell is closed at one end. The upper part is called the cap, and its diameter is slightly larger than the lower part is called the main body. These two parts are perfectly combined to form a sealed unit. Our hard capsules are produced before being filled in the two-piece hard caps. Our users fill the active ingredients or drugs into empty gelatin capsules. As the world’s population ages and we respond to COVID-19, health-conscious consumers need dosage forms that are easy to use, easy to swallow, and carry. It is an oral dosage form used to deliver life-saving drugs, minerals, vitamins or other health ingredients through supplements. These convenient packages enable reliable dosage, portability and high consumer compliance.

HOW LONG DOES IT TAKE HARD GELATIN CAPSULES TO DISSOLVE?

hard gelatin capsules we provided could be dissolved in the stomach within 20 to 30 minutes after swallowing under normal conditions. Depending on the application, different types of gelatin or additional process steps can affect the dissolution process. Certain types of gelatin dissolve faster than other types of gelatin when in contact with acidic liquids and higher temperatures (gastric conditions). For other applications, such as analgesics, a shell that dissolves faster is required. For the application of drugs targeting the intestinal tract, a slower dissolving shell is required.

Packaging, transportation, storage and filling of Huaxuan hard gelatin capsules

Package

Empty capsules are packed in food-grade antistatic plastic bags.
Then put these plastic bags into heavy-duty corrugated boxes.
Then seal the box with BOPP tapping from the top and bottom.
Finally, put the label on the cartons. the cartons have relevant information such as size, color, batch number, box number, and quantity.

Transportation

hard gelatin capsules in the box are transported by refrigerated container vehicles under conditions.
The temperature is maintained between 10°C and 30°C, and Rh is maintained between 40% and 65%.
All special vehicles used for capsule transportation are equipped with temperature data loggers to ensure that the temperature during transportation is within the specified range.

Warehousing/storage

When not in use, gelatin capsules should be stored in unopened packaging
The temperature and Rh during storage should be between 20°C to 35°C and 40% to 65%.

Other considerations:

Store hard empty capsules away from direct sunlight,hot water, air radiators, hot water pipes and steam pipes.
Store the capsules on the floor tray.
Store the capsules away from potential sources of water condensation, for example, under water pipes.
Do not store empty gelatin capsules shell in the refrigerator.

warn:

the opened plastic bag containing the capsule should be closed in the best way.moisture in capsule needs to be reduced during storage. Increase
Storage conditions beyond the recommended limits will result in damage to the quality of the capsule. then empty capsule would be hard to be saparated on the filling machine.

Shelf life

the above precautions must be taken during transportation and storage.Then hard Capsules shell can maintain good condition within 5 years from the date of production. Huaxuan gelatin capsule also could be saparated well in filling machine.